14. Cape Buffalo

Estimated Deaths Per Year: ~200
Location: Sub-Saharan Africa
Cape buffalo, often nicknamed the “Black Death,” are deceptively dangerous. They may look like oversized cattle, but they are one of the most aggressive animals in Africa. These animals weigh up to 900 kilograms (nearly 2,000 pounds) and can charge at speeds exceeding 50 km/h (30 mph).
What makes them especially lethal is their unpredictability. Cape buffaloes are known to charge with no warning signs — especially when they are wounded, threatened, or protecting a calf. Many fatal encounters occur with hunters, safari tourists, or villagers crossing their territory.
Their horns are not just for display. In an attack, the buffalo will lower its head and use its massive, curved horns to toss, gore, or crush its victim. Some attacks involve entire herds rushing to defend a wounded member, making escape almost impossible.
Despite their danger, Cape buffalo are essential to African ecosystems. However, locals living near game reserves and national parks must remain extremely cautious, especially during the dry season when buffaloes move closer to human settlements.